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N,N'-Dicyclohexylcarbodiimide: A Catalyst for Biochemical Advancements and Organic Synthesis

Time:2024-04-30

Introduction:
N,N'-Dicyclohexylcarbodiimide (DCC) stands as a cornerstone in both biochemical research and organic synthesis. This article delves into its properties, applications, and profound impact on advancing scientific endeavors in these fields.

Properties:
DCC(CAS number is 538-75-0), with its chemical formula C13H22N2 and molar mass of 206.33 g/mol, presents as a pale yellow liquid. It exhibits a melting point of 34-35°C and a boiling point of 122-124°C under reduced pressure. With a density of 1.247 g/mL at 25°C and a flash point of 190°F, DCC possesses physical characteristics conducive to a wide range of synthetic processes.

Applications:
As a vital biochemical reagent and dehydration condensation agent, DCC finds extensive utility in organic synthesis. Its versatility enables peptide synthesis, nucleic acid synthesis, and the formation of acids, anhydrides, aldehydes, and ketones. Moreover, DCC's role in glutathione dehydration underscores its significance in biochemical research.

Nature:
In its pristine form, DCC exists as white crystalline solids or yellowish transparent liquids. Despite limited solubility in water, it readily dissolves in organic solvents such as benzene, ethanol, and ether. This property renders it suitable for various synthetic applications across different solvent systems.

Use in Organic Synthesis:
DCC serves as a catalyst in dehydration condensation reactions, facilitating the efficient formation of peptide bonds and esters. Its coupling agent capabilities enhance the efficacy of peptide synthesis and nucleic acid assembly, driving progress in laboratory experimentation and industrial production.

Storage and Handling:
To preserve its stability and efficacy, DCC requires storage below +30°C in a dry environment shielded from moisture and direct sunlight. Adhering to proper storage protocols ensures the compound's integrity and longevity for sustained utilization in biochemical and organic synthesis endeavors.

Conclusion:
In conclusion, N,N'-Dicyclohexylcarbodiimide emerges as a catalyst for biochemical advancements and organic synthesis, fueling progress in scientific discovery and innovation. Its multifaceted applications, coupled with favorable physical properties, position DCC as an indispensable tool in the arsenal of researchers and chemists, driving transformative developments across various scientific disciplines.

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