Introduction:

2-Chloromandelic acid(CAS number is 10421-85-9), alternatively known as o-chloromandelic acid, stands as a pivotal compound in the realm of pharmaceutical synthesis and organic chemistry. This article delves into its properties, wide-ranging applications, and essential safety considerations across various industrial and laboratory settings.

Properties:

Characterized by a chemical formula of C8H7ClO3 and a molar mass of 186.59 g/mol, 2-Chloromandelic acid presents as white to yellowish crystals or powder. Its melting point spans a range of 90-93°C, while its boiling point is estimated around 266.91°C. With a density of approximately 1.3245 g/cm³ and a flash point of 165.7°C, it exhibits distinctive physical attributes crucial for its utilization in synthesis processes.

Applications:

2-Chloromandelic acid assumes a critical role as both a pharmaceutical intermediate and a general reagent in organic synthesis endeavors. Its versatility finds expression in the production of various pharmaceuticals, notably including clopidogrel, a medication instrumental in preventing blood clot formation associated with cardiovascular conditions. Furthermore, its utility extends to organic transformations, facilitating the introduction of the 2-chlorophenyl moiety into target molecules.

Safety Information:

Given its corrosive and irritant properties, careful handling and storage protocols are imperative when working with ortho-chloromandelic acid. Protective gear such as gloves, goggles, and lab coats should be worn to mitigate the risk of skin, eye, and respiratory irritation. Additionally, adherence to proper waste disposal procedures is essential to prevent environmental harm.

Conclusion:

In summary, 2-Chloromandelic acid emerges as an indispensable component in pharmaceutical synthesis, underpinning the production of vital medications and facilitating organic transformations in laboratory settings. While its significance in drug development is undeniable, stringent safety measures must be observed to ensure workplace safety and environmental stewardship throughout its utilization.