Introduction:
2-Chloroacetamide, also known as KM 101, Mergal AF, and Chloracetamide, is a significant compound used in organic synthesis and pharmaceutical intermediates. This article provides a detailed examination of its properties, applications, and safety considerations.
Properties:
- Molecular Formula: C2H4ClNO
- Molar Mass: 93.51 g/mol
- Density: 0.84 g/cm³
- Melting Point: 116-118°C (lit.)
- Boiling Point: 224.5°C
- Flash Point: 170°C
- Water Solubility: Soluble in water (90 g/L)
- Solubility: Soluble in water and absolute ethanol, very slightly soluble in ether
- Appearance: White crystal
- Color: White
Applications:
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Organic Synthesis:
- Intermediate for Chloroacetonitrile: 2-Chloroacetamide is crucial in the synthesis of chloroacetonitrile, which is used in various chemical reactions and industrial applications.
- Pharmaceutical Intermediates: It is used in synthesizing pharmaceutical compounds such as sulfamethoxazole pyrazine, making it essential in medicinal chemistry.
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Industrial Uses:
- Production of Sulfanilamide Derivatives: The compound is involved in synthesizing sulfanilamide-3-methoxy pyrazine, a compound with significant pharmaceutical applications.
Storage and Handling:
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Storage Conditions:
Store 2-Chloroacetamide below +30°C in a cool, ventilated, and dry place. It must be kept separate from food raw materials and protected from sunlight and moisture.
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Safety Measures:
Due to its irritant and corrosive nature, proper handling is crucial. Protective gloves and safety glasses should be worn to avoid skin and mucous membrane irritation. Follow standard protocols for storing and transporting irritant substances.
Safety Considerations:
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Irritant and Corrosive:
The compound can irritate and damage the skin and mucous membranes upon contact. Proper safety equipment and measures should be employed during handling to prevent exposure.
Conclusion:
2-Chloroacetamide is a vital compound in organic synthesis and pharmaceuticals. Its role as an intermediate in producing chloroacetonitrile and various pharmaceutical compounds highlights its importance. Adhering to safety protocols during handling and storage ensures its safe and effective use in industrial applications.
