Introduction:
Methyl acetoacetate (MAA) is a versatile organic compound with wide-ranging applications in the pharmaceutical, agricultural, and chemical industries.
Properties:
- Molecular Formula: C5H8O3
- CAS Number: 105-45-3
- Molar Mass: 116.12 g/mol
- Density: 1.076 g/mL at 25 °C (lit.)
- Melting Point: -80 °C (lit.)
- Boiling Point: 169-170 °C/70 mmHg (lit.)
- Flash Point: 158°F
- Water Solubility: 460 g/L (20 ºC)
- Solubility: Soluble in water
- Appearance: Transparent liquid
Applications:
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Agriculture:
- Pesticide Intermediate: Methyl acetoacetate serves as an intermediate in the synthesis of various pesticides, including hymmezol, dimethylsulfurol, ethylsulfurol, diazinon, and pyrifos. It is also used in producing herbicides like imidazoleetinic acid and rodenticides.
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Pharmaceutical Industry:
- Intermediate: It is widely used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. The compound plays a critical role in the preparation of active pharmaceutical ingredients (APIs).
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Chemical Industry:
- Solvent: Methyl acetoacetate is used as a solvent for cellulose ether and a mixed solvent for cellulose resin. It is also employed in the organic synthesis of dyes, polymer stabilizers, and other chemicals.
Storage and Handling:
- Storage Conditions: Methyl acetoacetate should be stored at 2-8°C in a cool and ventilated place. It is typically packaged in an aluminum barrel, and it is crucial to ensure that the lid is well sealed to prevent leakage or contamination. Fire protection measures should be in place, and the product should be stored and transported according to the regulations for flammable and toxic chemicals.
Safety Considerations:
- Handling Precautions: Due to its flammable nature, proper care should be taken during the handling and storage of methyl acetoacetate. Protective equipment such as gloves and goggles should be worn to prevent exposure, and the area should be well-ventilated to avoid inhalation of fumes.
- Fire Safety: Since methyl acetoacetate has a flash point of 158°F, it is essential to keep it away from open flames and high-temperature areas to minimize the risk of fire.
Conclusion:
Methyl acetoacetate is an essential chemical with diverse applications across various industries, including agriculture, pharmaceuticals, and chemicals. Its role as an intermediate in the synthesis of pesticides and pharmaceuticals highlights its importance in these fields. Adherence to safety protocols during storage and handling is crucial to ensure its safe and effective use.
